This study was carried out to investigate the prevalence, seasonal distribution and economic effects of hydatid cyst infection in slaughtered cattle of Muğla province. Data from the 2019 records of the Muğla Metropolitan Municipal Abattoir were studied retrospectively. Both direct and indirect calculation methods were used to determine the economic losses incurred due to hydatid cyst. Twenty-one out of 9.985 (0.21%) cattle were found to have been infected with hydatid cyst in 2019. The highest prevelance of infection was reported in February (1.17%), while no cases were observed in May, June and August. The direct economic loss attributed to liver destruction in Muğla province was 11,760 TL (1.950 $). The total indirect economic loss caused by hydatid cyst (carcass loss, milk production loss, decreased fecundity) was 122,691 TL (20,346 $). Cumulatively, the direct and indirect economic losses for hydatid cyst disease in Muğla province were 134,451 TL (22,296 $). According to our results, the prevalence of hydatid cyst in cattle of Muğla province was 0.21%, which was still lower than the average loss in Turkey in spite of the corresponding significant economic loss.