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Design, development, and evaluation of terbutaline sulfate sublingual tablets

Narendra Yadav, MangalSingh Panwar
Published: 1 January 2015

Abstract: Terbutaline sulphate is a selective B2 bronchodilator which is used in the treatment of asthma. Conventional Terbutaline tablets available in the market are not suitable where quick onset of action is required. Terbutaline sulphate sublingual tablets were prepared by using mannitol, microcrystalline cellulose pH102 (F1) and lactose monohydrate, microcrystalline cellulose pH102 (F4) as filler and its combination in different ratio, Crospovidone as superdisintegrant and sodium lauryl Sulphate as permeability enhancers by drug dispersion direct compression method.The formulation F1 found the 93.51% of % drug permeability, 8 seconds disintegration time and 96.95% drug release within one minute. The formulation F4 also found the 98.25% of drug permeability, 13 seconds disintegration time and 90.31% drug release within one minute. It was concluded that the sublingual tablet of Terbutaline sulphate can be formulated for sublingual absorption of drug in emergency treatment of asthma by Mannitol and Microcrystalline cellulose pH 102 in combination (75% and 25% respectively) or lactose monohydrate and Microcrystalline cellulose pH 102 in combination (75% and 25% respectively) as filler, Crospovidone as superdisintegrant, and Sodium Lauryl sulphate as permeability enhancer by direct compression drug dispersion method
Keywords: sodium / sulphate / sublingual tablets Terbutaline / treatment of asthma

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