Early Determination of Prognosis in Neonatal Moderate or Severe Hypoxic-Ischemic Encephalopathy
- 1 June 2021
- journal article
- research article
- Published by American Academy of Pediatrics (AAP) in PEDIATRICS
- Vol. 147 (6)
- https://doi.org/10.1542/peds.2020-048678
Abstract
BACKGROUND AND OBJECTIVES: Early determination of prognosis is important in neonates with hypoxic-ischemic encephalopathy (HIE). Our objective was to test scoring systems developed earlier (original scoring system) and develop new prognostic models. METHODS: Secondary analysis of data from the multicenter randomized controlled trial of longer, deeper, or usual care cooling in neonatal HIE (NCT01192776) that enrolled 364 neonates diagnosed with moderate or severe HIE. The primary outcome was death or moderate or severe disability at 18 to 22 months, and secondary outcome was death during initial hospitalization. Testing of early neurologic clinical examination (RESULTS: For death or disability, the original scoring system correctly classified 75% (95% confidence interval: 69%–81%), whereas the new scoring system correctly classified 78% (73%–82%), and the CART model correctly classified 76% (72%–81%). Early neurologic clinical examination also had a correct classification rate of 76% (71%–80%). Depth and duration of cooling did not affect prediction. Only a few components of the early neurologic examination were associated with poor outcome. For death, the original scoring system correctly classified 72% (66%–77%), the new scoring system 68% (63%–72%), the new CART model 87% (83%–90%), and early neurologic evaluation 81% (77%–85%). CONCLUSIONS: The 3 models (scoring system, CART, and early neurologic evaluation) were comparable in predicting death or disability. For in-hospital death, CART models were superior to scoring systems and early neurologic examination.This publication has 30 references indexed in Scilit:
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