A Mini-Review of Reactive Oxygen Species in Urological Cancer: Correlation with NADPH Oxidases, Angiogenesis, and Apoptosis
Open Access
- 22 October 2017
- journal article
- review article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 18 (10), 2214
- https://doi.org/10.3390/ijms18102214
Abstract
Oxidative stress refers to elevated reactive oxygen species (ROS) levels, and NADPH oxidases (NOXs), which are one of the most important sources of ROS. Oxidative stress plays important roles in the etiologies, pathological mechanisms, and treatment strategies of vascular diseases. Additionally, oxidative stress affects mechanisms of carcinogenesis, tumor growth, and prognosis in malignancies. Nearly all solid tumors show stimulation of neo-vascularity, termed angiogenesis, which is closely associated with malignant aggressiveness. Thus, cancers can be seen as a type of vascular disease. Oxidative stress-induced functions are regulated by complex endogenous mechanisms and exogenous factors, such as medication and diet. Although understanding these regulatory mechanisms is important for improving the prognosis of urothelial cancer, it is not sufficient, because there are controversial and conflicting opinions. Therefore, we believe that this knowledge is essential to discuss observations and treatment strategies in urothelial cancer. In this review, we describe the relationships between members of the NOX family and tumorigenesis, tumor growth, and pathological mechanisms in urological cancers including prostate cancer, renal cell carcinoma, and urothelial cancer. In addition, we introduce natural compounds and chemical agents that are associated with ROS-induced angiogenesis or apoptosis.Keywords
This publication has 160 references indexed in Scilit:
- Regulation of apoptosis by Bcl-2 cysteine oxidation in human lung epithelial cellsMolecular Biology of the Cell, 2013
- Activation of Androgen Receptor, Lipogenesis, and Oxidative Stress Converged by SREBP-1 Is Responsible for Regulating Growth and Progression of Prostate Cancer CellsMolecular Cancer Research, 2012
- Cadmium Increases HIF-1 and VEGF Expression through ROS, ERK, and AKT Signaling Pathways and Induces Malignant Transformation of Human Bronchial Epithelial CellsToxicological Sciences, 2011
- Oxidative Modification of Nuclear Mitogen-activated Protein Kinase Phosphatase 1 Is Involved in Transforming Growth Factor β1-induced Expression of Plasminogen Activator Inhibitor 1 in FibroblastsOnline Journal of Public Health Informatics, 2010
- Activation of NF-κB by Palmitate in Endothelial CellsArteriosclerosis, Thrombosis, and Vascular Biology, 2009
- Androgens induce oxidative stress and radiation resistance in prostate cancer cells though NADPH oxidaseProstate Cancer and Prostatic Diseases, 2009
- Expression of NADPH oxidase homologues and accessory genes in human cancer cell lines, tumours and adjacent normal tissuesFree Radical Research, 2009
- Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapyCancer Letters, 2008
- Free radicals and antioxidants in normal physiological functions and human diseaseThe International Journal of Biochemistry & Cell Biology, 2007
- Regulation of Nox and Duox enzymatic activity and expressionFree Radical Biology & Medicine, 2007