Bone Deformity due to Rickets and Osteomalacia in Children and Adolescents
- 25 October 2021
- journal article
- review article
- Published by Sciencedomain International in Journal of Pharmaceutical Research International
- Vol. 33 (47A), 59-65
- https://doi.org/10.9734/jpri/2021/v33i47a32989
Abstract
Rickets is a worldwide bone disease that is associated with disorders of calcium and phosphate homeostasis and can lead to short stature and joint deformities. Osteomalacia is a major metabolic bone disease that results from a chronic and severe deficiency of vitamin D or phosphate from any cause after growth has stopped. A deficiency of vitamin D or phosphate leads to defective bone mineralization and generalized or localized vague bone pain in various parts of the skeleton and / or proximal muscle weakness. Rickets and osteomalacia are two different clinical diseases with impaired bone mineralization. Rickets occurs throughout the growing skeleton in infants and children, while osteomalacia occurs in adults after fusion of the growth plates. Rickets and osteomalacia are increasingly common in Saudi Arabia, with vitamin D deficiency being the most common etiological cause. Early skeletal deformities can occur in infants, such as soft, thin skull bones, a condition known as craniotabes. In adults, as a result of demineralization, the bones become less rigid (soft bone) with pathological fractures. The diagnosis of both diseases is based on the medical history and physical examination, radiological characteristics, and biochemical tests. Management depends on the underlying etiology.Keywords
This publication has 18 references indexed in Scilit:
- Osteomalacia as a Result of Vitamin D DeficiencyRheumatic Disease Clinics of North America, 2012
- Rickets-vitamin D deficiency and dependencyIndian Journal of Endocrinology and Metabolism, 2012
- Nutritional Rickets-ReviewJournal of Clinical Research in Pediatric Endocrinology, 2010
- Recent trends and clinical features of childhood vitamin D deficiency presenting to a children's hospital in GlasgowArchives of Disease in Childhood, 2010
- Osteomalacia as a Result of Vitamin D DeficiencyEndocrinology and Metabolism Clinics of North America, 2010
- Hypophosphatemia: the common denominator of all ricketsJournal of Bone and Mineral Metabolism, 2009
- CorrectionsArchives of Disease in Childhood: Fetal & Neonatal, 2007
- Changes in Bone Mineral Density Following Treatment of OsteomalaciaJournal of Clinical Densitometry, 2006
- The re-emerging burden of rickets: a decade of experience from SydneyArchives of Disease in Childhood, 2005
- Musculoskeletal manifestations of osteomalacia and ricketsBest Practice & Research Clinical Rheumatology, 2003