Distribution Genotype High Risk (HR) And Low Risk (LR) Human Papillomavirus (HPV) at Condyloma Acuminata
Open Access
- 30 June 2021
- journal article
- Published by Medknow in Biomolecular and Health Science Journal
- Vol. 4 (1), 10-14
- https://doi.org/10.20473/bhsj.v4i1.26250
Abstract
Introduction: Condyloma acuminata that is also known as genital warts are one of the most common sexually transmitted that caused by infection of Human papillomavirus (HPV). Persistent infection of Low Risk (LR) or High risk (HR) HPV is a risk factor for progress into benign or malignant cancer. The objective is to analyze distribution of genotype LR-HPV and HR-HPV at condyloma acuminata in anogenital region. Methods: A cross sectional study using were 36 lesions from men and women of condyloma acuminata patients. All subject signed the informed consent and ethic obtained from our institution, number 382/Panke.KKE/V/2016. The specimen was used to histopathological examination and to identified 40 genotypes of HPV using a reverse line blot assay. Results: The All patients were diagnosed as condyloma acuminata, some with focus dysplasia and koilocytosis. All patients were positive for HPV, including LR-HPV were HPV 6, 11, 42, 54, 61, 81,87,89 and HR-HPV were HPV 18, 26, 45, 51, 52, 66, 67, 68B, 69, 82. The single infection of LR-HPV was 44.4%, multiple infection LR/LR-HPV was 13,9% and the multiple infection of LR/HR-HPV was 41.7%. The LR-HPV infected 70,6% and HR-HPV infected 29,4%. Conclusion: LR-HPV is the major infection of condyloma acuminata, in single infection or multiple infection with HR-HPV. The most common infections were HPV 11, followed by HPV 6, HPV 18, HPV 51, and HPV 82. The determination of genotype of HPV can be used to predict the malignant transformation.Keywords
This publication has 22 references indexed in Scilit:
- Human Papillomavirus Virus (HPV) Genotype- and Age-Specific Analyses of External Genital Lesions Among Men in the HPV Infection in Men (HIM) StudyThe Journal of Infectious Diseases, 2014
- A Clinical and Pathological Overview of Vulvar Condyloma Acuminatum, Intraepithelial Neoplasia, and Squamous Cell CarcinomaBioMed Research International, 2014
- Genital warts: comparing clinical findings to dermatoscopic aspects, in vivo reflectance confocal features and histopathologic examAnais Brasileiros de Dermatologia, 2014
- Systematic review of the incidence and prevalence of genital wartsBMC Infectious Diseases, 2013
- Different DNA damage and cell cycle checkpoint control in low‐ and high‐risk human papillomavirus infections of the vulvaInternational Journal of Cancer, 2011
- A review of human carcinogens—Part B: biological agentsPublished by Elsevier BV ,2009
- Human Papillomavirus Genotype Distribution in External Acuminata Condylomata: A Large French National Study (EDiTH IV)Clinical Infectious Diseases, 2008
- Risk Factors for Anogenital Human Papillomavirus Infection in MenThe Journal of Infectious Diseases, 2007
- Cancer risk among patients with condylomata acuminataInternational Journal of Cancer, 2006
- External Genital Warts: Diagnosis, Treatment, and PreventionClinical Infectious Diseases, 2002