Steric Influence on Reactions of Benzyl Potassium Species with CO
Open Access
- 30 September 2021
- journal article
- research article
- Published by Wiley in Chemistry – An Asian Journal
- Vol. 16 (22), 3640-3644
- https://doi.org/10.1002/asia.202101127
Abstract
Reactions of benzyl potassium species with CO are shown to proceed via transient carbene-like intermediates that can undergo either dimerization or further CO propagation. In a sterically unhindered case, formal dimerization of the carbene is the dominant reaction pathway, as evidence by the isolation of ((Ph3SiO)(PhCH2)C)22 and PhCH2C(O)CH(OH)CH2Ph 3. Reactions with increasingly sterically encumbered reagents show competitive reaction pathways involving intermolecular dimerization leading to species analogous to 2 and 3 and those containing newly-formed five-membered rings tBu2C6H2(C(OSiR3)C(OSiR3)CH2) (R = Me 6, Ph 7). Even further encumbered reagents proceed to either dimerize or react with additional CO to give a ketene-like intermediates, thus affording a 7-membered tropolone derivative 14 or the dione (3,5-tBu2C6H3)3C6H2CH2C(O))215.Keywords
Funding Information
- John Simon Guggenheim Memorial Foundation
- Deutsche Forschungsgemeinschaft (SPP1807)
- China Scholarship Council
This publication has 48 references indexed in Scilit:
- A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-PuThe Journal of Chemical Physics, 2010
- Climbing the Density Functional Ladder: Nonempirical Meta–Generalized Gradient Approximation Designed for Molecules and SolidsPhysical Review Letters, 2003
- Reaction of o-Oxazolinylphenyllithium with Carbon Monoxide. Carbonylative Cyclization via an Aroyllithium IntermediateThe Journal of Organic Chemistry, 2000
- Carbonylation of various organolithium reagents. A novel approach to heterocycles via intramolecular trapping of aromatic acyllithiumsJournal of the Chemical Society, Perkin Transactions 1, 1999
- Progress in hydroformylation and carbonylationJournal of Molecular Catalysis A: Chemical, 1995
- Intramolecular conversions of acyllithium. Cyclization in the reaction of carbon monoxide with [1-(silyl)vinyl]lithiumJournal of the American Chemical Society, 1990
- Acyllithium to lithium enolate conversion by a 1,2-silicon shift. A shortcut to acylsilane enolatesJournal of the American Chemical Society, 1984
- Insertion of carbon monoxide into carbon-lithium bonds. A convenient one-step synthesis of 1,2-diketone diaryl derivativesThe Journal of Organic Chemistry, 1982
- Carbonylation of aryllithium reagents in the presence of alkyl halides: one-pot synthesis of diarylalkyl carbinols and derivativesThe Journal of Organic Chemistry, 1981
- Synthese aromatischer OxyaldehydeEuropean Journal of Inorganic Chemistry, 1898