Cannabinoids Modulate Neuronal Activity and Cancer by CB1 and CB2 Receptor-Independent Mechanisms
Open Access
- 10 October 2017
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Pharmacology
- Vol. 8, 720
- https://doi.org/10.3389/fphar.2017.00720
Abstract
Cannabinoids include the active constituents of Cannabis or are molecules that mimic the structure and/or function of these Cannabis-derived molecules. Cannabinoids produce many of their cellular and organ system effects by interacting with the well-characterized CB1 and CB2 receptors. However, it has become clear that not all effects of cannabinoid drugs are attributable to their interaction with CB1 and CB2 receptors. Evidence now demonstrates that cannabinoid agents produce effects by modulating activity of the entire array of cellular macromolecules targeted by other drug classes, including: other receptor types; ion channels; transporters; enzymes, and other protein- and non-protein cellular structures. This review summarizes evidence for these interactions in the CNS and in cancer, and is organized according to the cellular targets involved. The CNS represents a well-studied area and cancer is emerging in terms of understanding mechanisms by which cannabinoids modulate their activity. Considering the CNS and cancer together allows identification of non-cannabinoid receptor targets that are shared and divergent in both systems. This comparative approach allows the identified targets to be compared and contrasted, suggesting potential new areas of investigation. It also provides insight into the diverse sources of efficacy employed by this interesting class of drugs. Obtaining a comprehensive understanding of the diverse mechanisms of cannabinoid action may lead to the design and development of therapeutic agents with greater efficacy and specificity for their cellular targets.This publication has 167 references indexed in Scilit:
- Extrasynaptic GABAA Receptors: Their Function in the CNS and Implications for DiseaseNeuron, 2012
- The role of the EP receptors for prostaglandin E2 in skin and skin cancerCancer and Metastasis Reviews, 2011
- Cannabinoid receptor antagonists AM251 and AM630 activate TRPA1 in sensory neuronsNeuropharmacology, 2011
- A review of the mammalian unfolded protein responseBiotechnology & Bioengineering, 2011
- Resolution of inflammation by N‐arachidonoylglycineJournal of Cellular Biochemistry, 2011
- Arachidonoyl ethanolamide (AEA)‐induced apoptosis is mediated by J‐series prostaglandins and is enhanced by fatty acid amide hydrolase (FAAH) blockadeMolecular Carcinogenesis, 2011
- Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer PathogenesisCell, 2010
- The therapeutic potential of novel cannabinoid receptorsPharmacology & Therapeutics, 2009
- Role of ionotropic cannabinoid receptors in peripheral antinociception and antihyperalgesiaTrends in Pharmacological Sciences, 2009
- Alcohol dehydrogenase-catalyzed in vitro oxidation of anandamide to N-arachidonoyl glycine, a lipid mediator: Synthesis of N-acyl glycinalsBioorganic & Medicinal Chemistry Letters, 2009