Possible Antibacterial Activity of Curcumin and Mangiferin in Patients with Helicobacter pylori –Associated Functional Dyspepsia

Abstract

Journal of clinical gastroenterology is part of the Juniper publishers which is devoted to publish subject-specific articles focused on the needs of individual research communities across all areas of biology and medicine. Since the introduction to the scientific community by Marshall and Warren in 1982, the gram-negative bacterium Helicobacter pylori (H. pylori or HP), is now recognized as the primary causative agent associated with the development of gastritis and peptic ulcer disease. The effectiveness of many of the frequently recommended antibiotic-based H. pylori eradication regimens has been increasingly compromised by antimicrobial resistance and the higher incidence of adverse effects. Some in vitro studies have shown the effectiveness of curcumin and mangiferin against Helicobacter pylori. The aim of this study is to test the efficacy of curcumin and mangiferin as components of dual or triple proton pump inhibitor-based H. pylori eradication regimens in patients with H. pylori-associated functional dyspepsia.