Determinants of Vitamin D Status of Women of Reproductive Age in Dhaka, Bangladesh: Insights from Husband–Wife Comparisons
Open Access
- 1 November 2019
- journal article
- research article
- Published by Elsevier BV in Current Developments in Nutrition
- Vol. 3 (11), nzz112
- https://doi.org/10.1093/cdn/nzz112
Abstract
Background: Vitamin D deficiency is common among women of reproductive age (WRA) in Bangladesh, but the causes remain unclear. Objective: To explain the high prevalence of vitamin D deficiency in WRA in Dhaka, Bangladesh, we compared the vitamin D status of pregnant women with that of their husbands and between pregnant and nonpregnant states. Methods: This study was an observational substudy of the Maternal Vitamin D for Infant Growth trial conducted in Dhaka, Bangladesh. Women (n = 1300) were enrolled in the second trimester of pregnancy and randomly assigned to 1 of 5 arms consisting of different doses of vitamin D supplements or placebo, with 1 arm continuing supplementation until 6 mo postpartum. A subgroup of trial participants and their husbands with plasma 25-hydroxyvitamin D [25(OH)D] concentration measurements (n = 84), and placebo-group trial participants with serum 25(OH)D measured in the second trimester of pregnancy and 6 mo postpartum (n = 89) were studied using linear mixed-effects regression models. Results: The mean +/- SD plasma 25(OH)D in pregnant women in the second trimester was 23 +/- 11 nmol/L. Adjusting for age and season, 25(OH)D of pregnant women was 30 nmol/L lower (95% CI: -36, -25 nmol/L) than that of men. Only 9% of total variance in 25(OH)D was explained by factors shared by spousal pairs. Selected nonshared factors (BMI, time spent outdoors, involvement in an outdoor job, sunscreen use) did not explain the association of sex with 25(OH)D. Adjusting for age, season, and BMI, 25(OH)D was similar during pregnancy and 6 mo postpartum (mean difference: -2.4 nmol/L; 95% CI: -5.3, 0.4 nmol/L). Conclusions: In Dhaka, WRA have substantially poorer vitamin D status than men. Variation in 25(OH)D is not greatly influenced by determinants shared by spouses. Measured nonshared characteristics or pregnancy did not account for the gender differential in 25(OH)D. This trial was registered at clinicaltrials.gov as NCT01924013.Keywords
Funding Information
- Bill & Melinda Gates Foundation (OPP1066764)
This publication has 34 references indexed in Scilit:
- Influence of gender roles and rising food prices on poor, pregnant women’s eating and food provisioning practices in Dhaka, BangladeshReproductive Health, 2013
- Acute Erythemal Ultraviolet Radiation Causes Systemic Immunosuppression in the Absence of Increased 25-Hydroxyvitamin D3 Levels in Male MicePLOS ONE, 2012
- Comparison of vitamin D deficiency in Saudi married couplesEuropean Journal of Clinical Nutrition, 2012
- Vitamin D Status in Jordan: Dress Style and Gender DiscrepanciesAnnals of Nutrition and Metabolism, 2011
- Prevalence of vitamin D deficiency among Turkish, Moroccan, Indian and sub-Sahara African populations in Europe and their countries of origin: an overviewOsteoporosis International, 2010
- Existing and potentially novel functional markers of vitamin D status: a systematic reviewThe American Journal of Clinical Nutrition, 2009
- Vitamin D deficiency and low bone status in adult female garment factory workers in BangladeshBritish Journal of Nutrition, 2008
- Who, what, where and when—influences on cutaneous vitamin D synthesisProgress in Biophysics and Molecular Biology, 2006
- Vitamin D deficiency: a concern in premenopausal Bangladeshi women of two socio-economic groups in rural and urban regionEuropean Journal of Clinical Nutrition, 2002
- Vitamin D deficiency in adult British Hindu Asians: a family disorder.BMJ, 1985