Effect of Bifidobacterium animalis subsp. lactis MN-Gup on constipation and the composition of gut microbiota
Open Access
- 24 February 2021
- journal article
- research article
- Published by Brill in Beneficial Microbes
- Vol. 12 (1), 31-42
- https://doi.org/10.3920/bm2020.0023
Abstract
Probiotics have been reported to be associated with the alleviation of constipation. The aim of this study was to detect and determine the effect of Bifidobacterium animalis subsp. lactis MN-Gup (MN-Gup) on the alleviation of constipation in BALB/c mice and humans, and to elucidate the mechanisms underlying its effect by measuring changes in the concentration of short-chain fatty acids and the composition of microbes in human faeces. BALB/c mice were given MN-Gup by gavage for 14 days. On the 8th day of this treatment, constipation was induced by the application of diphenoxylate via gavage. The results showed that MN-Gup significantly decreased the first black stool defecation time, and significantly increased black faecal wet weight, black faecal number and the gastric-intestinal transit rate (PBifidobacterium, Ruminoccaceae_UCG-002 and Ruminoccaceae_UCG-005 were significantly increased after intake of MN-Gup yogurt. These results showed that MN-Gup could relieve constipation related to increased acetate-producing Bifidobacterium, Ruminoccaceae_UCG-002 and Ruminoccaceae_UCG-005.Keywords
This publication has 35 references indexed in Scilit:
- Untangling the Genetic Basis of Fibrolytic Specialization by Lachnospiraceae and Ruminococcaceae in Diverse Gut CommunitiesDiversity, 2013
- Human gut microbiome viewed across age and geographyNature, 2012
- Intestinal Microbiota in Healthy Adults: Temporal Analysis Reveals Individual and Common Core and Relation to Intestinal SymptomsPLOS ONE, 2011
- Dose-response effect ofBifidobacterium lactisHN019 on whole gut transit time and functional gastrointestinal symptoms in adultsScandinavian Journal of Gastroenterology, 2011
- Fermented milk containingLactobacillus caseistrain Shirota reduces incidence of hard or lumpy stools in healthy populationInternational Journal of Food Sciences and Nutrition, 2011
- Mechanisms of Microbial Hydrogen Disposal in the Human Colon and Implications for Health and DiseaseAnnual Review of Food Science and Technology, 2010
- Methane and the Gastrointestinal TractDigestive Diseases and Sciences, 2009
- Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN‐173 010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipationAlimentary Pharmacology & Therapeutics, 2008
- The Health-Related Quality of Life and Economic Burden of ConstipationPharmacoEconomics, 2005
- Stool Form Scale as a Useful Guide to Intestinal Transit TimeScandinavian Journal of Gastroenterology, 1997