Mechanical feedback controls the emergence of dynamical memory in growing tissue monolayers
- 22 June 2022
- journal article
- research article
- Published by AIP Publishing in The Journal of Chemical Physics
- Vol. 156 (24), 245101
- https://doi.org/10.1063/5.0087815
Abstract
The growth of a tissue, which depends on cell–cell interactions and biologically relevant processes such as cell division and apoptosis, is regulated by a mechanical feedback mechanism. We account for these effects in a minimal two-dimensional model in order to investigate the consequences of mechanical feedback, which is controlled by a critical pressure, pc. A cell can only grow and divide if its pressure, due to interaction with its neighbors, is less than pc. Because temperature is not a relevant variable, the cell dynamics is driven by self-generated active forces (SGAFs) that arise due to cell division. We show that even in the absence of intercellular interactions, cells undergo diffusive behavior. The SGAF-driven diffusion is indistinguishable from the well-known dynamics of a free Brownian particle at a fixed finite temperature. When intercellular interactions are taken into account, we find persistent temporal correlations in the force–force autocorrelation function (FAF) that extends over a timescale of several cell division times. The time-dependence of the FAF reveals memory effects, which increases as pc increases. The observed non-Markovian effects emerge due to the interplay of cell division and mechanical feedback and are inherently a non-equilibrium phenomenon.Funding Information
- Welch Foundation (F-0019)
- National Science Foundation (PHY 17-08128, PHY-1522550)
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