Effect of hormonal manipulation using clomiphene citrate prior to microdissection testicular sperm retrieval
Open Access
- 1 January 2021
- journal article
- research article
- Published by Medknow in Urology Annals
- Vol. 13 (3), 254-257
- https://doi.org/10.4103/ua.ua_129_20
Abstract
Introduction: Microdissection Testicular Sperm Extraction (micro-TESE) is a surgical method used for retrieving sperm from men with non-obstructive azoospermia. Clomiphene citrate (CC) is a selective estrogen receptor modulator (SERM) that stimulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH) production. It is believed that treating patients with CC prior to micro-TESE increases the chance of sperm retrieval. Methods: This retrospective study was conducted in a tertiary care center in Riyadh, Saudi Arabia and included all patients who underwent Micro-TESE from August 2015 to November 2018. Data related to the pre-surgery hormonal levels, testicular volume, and associated genetic abnormalities were collected. chi-square and t-test were used to compare variables. A p-value of less than 0.05 was considered significant. Results: A total of 122 patients were included in this study, with 30.0% (n=37) treated with CC. The overall sperm retrieval rate was 44.3%. Micro-TESE results were not statistically affected by age, testosterone levels, Klinefelter syndrome, or taking CC. However, higher testicular volumes and lower LH and FSH levels had more positive micro-TESE results. Conclusion: In conclusion, Micro-TESE results were not affected by CC, age or testicular volume.Keywords
This publication has 23 references indexed in Scilit:
- Predictive factors of successful microdissection testicular sperm extractionBasic and Clinical Andrology, 2013
- Micro-dissection testicular sperm extraction as an alternative for sperm acquisition in the most difficult cases of Azoospermia: Technique and preliminary results in IndiaJournal of Human Reproductive Sciences, 2013
- Aromatase inhibitors for male infertilityFertility and Sterility, 2012
- Optimization of spermatogenesis‐regulating hormones in patients with non‐obstructive azoospermia and its impact on sperm retrieval: a multicentre studyBJU International, 2012
- Role of Optimizing Testosterone Before Microdissection Testicular Sperm Extraction in Men with Nonobstructive AzoospermiaJournal of Urology, 2012
- Effect of pentoxifylline on semen parameters, reproductive hormones, and seminal plasma antioxidant capacity in men with idiopathic infertility: a randomized double-blind placebo-controlled studyInternational Urology and Nephrology, 2010
- Successful Fertility Treatment for Klinefelter's SyndromeJournal of Urology, 2009
- An Evidence-Based Perspective to the Medical Treatment of Male Infertility: A Short ReviewUrologia Internationalis, 2009
- Clomiphene Administration for Cases of Nonobstructive Azoospermia: A Multicenter StudyJournal of Andrology, 2005
- OUTCOME OF GONADOTROPIN THERAPY FOR MALE HYPOGONADOTROPIC HYPOGONADISM AT UNIVERSITY AFFILIATED MALE INFERTILITY CENTERS: A 30-YEAR RETROSPECTIVE STUDYJournal of Urology, 2005