New Search

Export article
Open Access

Cytotoxic Activity of Hyptis Pectinate Extracts on MCF-7 Human Breast Cancer Cells

Nur Dina Amalina, Meiny Suzery, Bambang Cahyono
Indonesian Journal of Cancer Chemoprevention , Volume 11, pp 1-6; doi:10.14499/indonesianjcanchemoprev11iss1pp1-6

Abstract: Hyptis pectinata (L.) poit, popularly known in the world as “comb bushmint” is a medicinal plant commonly used for the treatment of throat and skin inflammations, bacterial infection, pain and cancer. The objective of this research is to determine the cytotoxic and antiproliferative effect under Hyptis pectinata ethanolic extract (HPE) treatment on breast cancer cells. The effect HPE of on cytotoxicity was examined by MTT assay on MCF-7 breast cancer cells. This assay also used to determine cell proliferation over 3 days of treatment with 1.5 – 100 µg/mL HPE. HPE showed that exhibited cytotoxic effects with IC50 value of 30 µg/mL for 24 hours and changes the physiological morphology on MCF-7 cells. Interestingly, the treatment of HPE for 48 and 72 hours highly decreases cell viability on MCF-7 with dose and time-dependent manner compared to untreated cells. These results indicate that HPE has antiproliferative activities and maybe the potential to be developed as a natural chemotherapeutic agent.Keywords: Hyptis pectinata (L.) poit extract, cytotoxicity, antiproliferative, MCF-7 cells
Keywords: Treatment / breast cancer / MTT assay / cytotoxic / cancer cells / MCF / Hyptis pectinata / Hours / µg/ml

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

Share this article

Click here to see the statistics on "Indonesian Journal of Cancer Chemoprevention" .
Cited by 1 articles
    Back to Top Top