Electrochemical determination of Thyroxine Hormone in Human Blood through Magnetic Nanoparticles Composite Electrode

Abstract

As a novel performance, silicon oxide was firstly loaded on Fe3O4 magnetic nanoparticles substrate (Fe3O4@SiO2), and then functionalized with -NH2 group (Fe3O4@SiO2@NH2). The resultant array was reacted with terephthalaldehyde schiff-base to fabricate novel hierarchical magnetic nano-composites. A sensitive sensor involving immobilized gold nanoparticles and nano-composites in electropolymerized polypyrrole was achieved. Cyclic voltammetry (CV), scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS) techniques were demonstrated the morphology of modified electrode's surface and electrochemical behavior of thyroxine on this platform. We believe that such kind of bio-devices possesses the prominent potential to trace determination of bio-compounds in biological fluids with excellent accuracy and precise analysis. This sensor covered a linear concentration range from 10 to 210 nM of thyroxine with the detection limit of 8 nM.