Mature Adult Mice With Exercise-Preconditioning Show Better Recovery After Intracerebral Hemorrhage
- 12 April 2021
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Stroke
- Vol. 52 (5), 1861-1865
- https://doi.org/10.1161/strokeaha.120.032201
Abstract
Background and Purpose: Physical exercise offers therapeutic potentials for several central nervous system disorders, including stroke and cardiovascular diseases. However, it is still mostly unknown whether and how exercise preconditioning affects the prognosis of intracerebral hemorrhage (ICH). In this study, we examined the effects of preconditioning on ICH pathology in mature adult mice using treadmill exercise. Methods: Male C57BL/6J (25-week old) mice were subjected to 6 weeks of treadmill exercise followed by ICH induction. Outcome measurements included various neurological function tests at multiple time points and the assessment of lesion volume at 8 days after ICH induction. In addition, plasma soluble factors and phagocytotic microglial numbers in the peri-lesion area were also measured to determine the mechanisms underlying the effects of exercise preconditioning. Results: The 6-week treadmill exercise preconditioning promoted recovery from ICH-induced neurological deficits in mice. In addition, mice with exercise preconditioning showed smaller lesion volumes and increased numbers of phagocytotic microglia. Furthermore, the levels of several soluble factors, including endostatin, IGFBP (insulin-like growth factor-binding protein)-2 and -3, MMP (matrix metallopeptidase)-9, osteopontin, and pentraxin-3, were increased in the plasma samples from ICH mice with exercise preconditioning compared with ICH mice without exercise. Conclusions: These results suggest that mice with exercise preconditioning may suffer less severe injury from hemorrhagic stroke, and therefore, a habit of physical exercise may improve brain health even in middle adulthood. Download figure Download PowerPointThis publication has 9 references indexed in Scilit:
- Effects of voluntary and forced exercises on motor function recovery in intracerebral hemorrhage ratsNeuroReport, 2020
- Osteopontin Peptide Icosamer Containing RGD and SLAYGLR Motifs Enhances the Motility and Phagocytic Activity of MicrogliaExperimental Neurobiology, 2017
- Health Outcomes Associated with Polypharmacy in Community‐Dwelling Older Adults: A Systematic ReviewJournal of the American Geriatrics Society, 2014
- MRI-Based Analysis of Intracerebral Hemorrhage in Mice Reveals Relationship between Hematoma Expansion and the Severity of SymptomsPLOS ONE, 2013
- The immunology of stroke: from mechanisms to translationNature Medicine, 2011
- Intracerebral haemorrhageThe Lancet, 2009
- Hematoma Resolution as a Therapeutic Target: The Role of Microglia/MacrophagesStroke, 2008
- Prediction of Functional Outcome in Patients With Primary Intracerebral HemorrhageStroke, 2008
- Reduced Risk of Intracerebral Hemorrhage With Dynamic Recreational Exercise but Not With Heavy Work ActivityStroke, 2002