No significant association between SNPs in the CLOCK and ADH4 genes and susceptibility to cluster headaches: A systematic review and meta‐analysis
- 18 April 2022
- journal article
- review article
- Published by Wiley in Annals of Human Genetics
- Vol. 86 (4), 159-170
- https://doi.org/10.1111/ahg.12467
Abstract
Background The circadian locomotor output cycles kaput (CLOCK) gene and the alcohol dehydrogenase 4 (ADH4) gene are promising candidates for susceptibility to cluster headaches (CH). Associations of the three single nucleotide polymorphisms (SNPs)-CLOCK SNP rs1801260 and ADH4 SNPs rs1800759, and rs1126671-with CH were studied previously, but the results were inconsistent. Methods Associations between the three SNPs (rs1801260, rs1126671, and rs1800759) and CH risk were separately assessed by pooled odds ratios (ORs) along with 95% confidence intervals (95% CIs) based on five different genetic models. Methodological quality was assessed using the Newcastle-Ottawa Quality Assessment Scale (NOS). All statistical analyses were carried out with RevMan 5.3 software. Results Eight studies involving 1437 CH patients and 2541 healthy controls were selected for quantitative synthesis, from five studies on CLOCK rs1801260, five on ADH4 rs1800759, and three on ADH4 rs1126671. Our pooled data did not support associations between the three SNPs (rs1801260 in the CLOCK gene, rs1800759 and rs1126671 in the ADH4 gene) and susceptibility to CH (rs1801260: OR 1.10, 95% CI: 0.95-1.28; p = 0.19; rs1800759: OR 1.06, 95% CI: 0.93-1.22; p = 0.37; and rs1126671: OR 1.09, 95% CI: 0.92-1.28; p = 0.32). Conclusion We found no significant associations between the three SNPs (rs1801260 in the CLOCK gene and rs1800759 and rs1126671 in the ADH4 gene) and the susceptibility to CH across both Caucasian and Asian ethnicities in our meta-analysis.Keywords
Funding Information
- National Natural Science Foundation of China (No. 81072852)
This publication has 55 references indexed in Scilit:
- Cluster headacheBMJ, 2012
- MTHFR 677C>T Polymorphism and Cluster HeadacheHeadache: The Journal of Head and Face Pain, 2010
- Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analysesEuropean Journal of Epidemiology, 2010
- Cluster Headache is Associated With theAlcohol Dehydrogenase 4(ADH4) GeneHeadache: The Journal of Head and Face Pain, 2010
- Haplotype Analysis Confirms the Association Between the HCRTR2 Gene and Cluster HeadacheHeadache: The Journal of Head and Face Pain, 2008
- The Incidence and Prevalence of Cluster Headache: A Meta-Analysis of Population-Based StudiesCephalalgia, 2008
- Cluster Headache: Clinical Presentation, Lifestyle Features, and Medical TreatmentHeadache: The Journal of Head and Face Pain, 2006
- Lack of Association between the 3092 T°C Clock Gene Polymorphism and Cluster HeadacheCephalalgia, 2005
- Association of Genetic Variants in Alcohol Dehydrogenase 4 With Alcohol Dependence in Brazilian PatientsAmerican Journal of Psychiatry, 2005
- Episodic Cluster Headache II: High Tobacco and Alcohol Consumption in Males1Headache: The Journal of Head and Face Pain, 1992