Investigating Pregnancy and Its Complications Using Circulating Cell-Free RNA in Women's Blood During Gestation
Open Access
- 14 December 2020
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Pediatrics
Abstract
In recent years, there have been major advances in the application of non-invasive techniques to predict pregnancy-related complications, for example by measuring cell-free RNA (cfRNA) in maternal blood. In contrast to cell-free DNA (cfDNA), which is already in clinical use to diagnose fetal aneuploidy, circulating RNA levels can correspond with tissue-specific gene expression and provide a snapshot of prenatal health across gestation. Here, we review the physiologic origins of cfRNA and its novel applications and corresponding challenges to monitor fetal and maternal health and predict pregnancy-related complications.Funding Information
- Bill and Melinda Gates Foundation
This publication has 54 references indexed in Scilit:
- Trash or Treasure: extracellular microRNAs and cell-to-cell communicationFrontiers in Genetics, 2013
- Early Administration of Low-Dose Aspirin for the Prevention of Preterm and Term Preeclampsia: A Systematic Review and Meta-AnalysisFetal Diagnosis and Therapy, 2012
- Design and validation issues in RNA-seq experimentsBriefings in Bioinformatics, 2011
- Insights into fetal and neonatal development through analysis of cell-free RNA in body fluidsEarly Human Development, 2010
- Pitfalls of supervised feature selectionBioinformatics, 2009
- The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR ExperimentsClinical Chemistry, 2009
- Noninvasive diagnosis of fetal aneuploidy by shotgun sequencing DNA from maternal bloodProceedings of the National Academy of Sciences of the United States of America, 2008
- Gene expression analysis in pregnant women and their infants identifies unique fetal biomarkers that circulate in maternal bloodJCI Insight, 2007
- Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cellsNature, 2007
- A gene atlas of the mouse and human protein-encoding transcriptomesProceedings of the National Academy of Sciences of the United States of America, 2004