Plants are a source of first-line treatment for most humans, particularly in Africa and offer nutrition for most terrestrial ecosystems. The world's attention have been called repeatedly to the therapeutic marvels of plants, one of which is Garcinia kola. This study aims to determine the antisalmonella efficacy of several Garcinia kola leaf and seed extracts. Extracts of leaves, seeds, and seed/leaf were obtained using methanol and ethanol as extraction solvents. Inoculated Salmonella typhi were observed for 24 hours using the well diffusion method to determine zones of inhibition. All extracts were found to be effective against S. typhi. 100/50 mg/ml methanol leave extract produced a 14/12mm zone of inhibition, whereas 100/50 mg/ml methanol seed extract produced a 13/11mm zone of inhibition. 100/50 mg/ml ethanol leave extract showed a 17/10mm inhibition zone, while 100/50 mg/ml ethanol seed extract showed a 16/14mm inhibition zone. The inhibition zone of methanol seed/leaf extract of 100/50 mg/ml was 17/12mm, while the inhibition zone of ethanol seed/leaf extract was 19/14mm. While all concentrations of plant extracts were effective against S. typhi, greater concentrations created larger zones of inhibition and the plant extracts outperformed the control. Seed/leaf extracts outperformed seed extract and leaf extract in most cases. The results showed that ethanol was a better extraction liquid and that the leaf extracts were more potent; however, this is not true in all cases. To stimulate local mitigation of illnesses caused by Salmonella typhi, more research on the antisalmonella effectiveness of Garcinia kola seed and leaf extracts should be done.