Maximal pulmonary ventilation and lactate affect the anaerobic performance in young women exposed to hypobaric hypoxia
Open Access
- 8 February 2023
- journal article
- research article
- Published by Frontiers Media SA in Frontiers in Physiology
- Vol. 14, 1110477
- https://doi.org/10.3389/fphys.2023.1110477
Abstract
Background: Athletes, tourists, and mining workers from all over the world ascend daily to an altitude greater than 3.000 meters above sea level to perform different activities, all of which demand physical effort. A ventilation increase is the first mechanism once the chemoreceptors perceive the hypoxia and is key to maintaining blood oxygen levels during acute exposure to high altitude and to buffering lactic acidosis during exercise. It has been observed that gender is a variable that can influence the ventilatory response. Still, the available literature is limited due to the few studies considering women as study subjects. The influence of gender on anaerobic performance and its effects in high altitude (HA) environments have been poorly studied. Objective: The objectives of this study were to evaluate anaerobic performance in young women exposed to high altitude and to compare the physiological response to multiple sprints between women and men measured by ergospirometry. Methodology: Nine women and nine men (22,9±3,2 years old) carried out the multiple-sprint anaerobic test under two conditions, sea level and high altitude. Results: In the first 24 hours of exposure to high altitude, lactate levels were higher in women than men (2.57±0.4 Mmol/L, 2.18±0.3 Mmol/L, respectively; p0.005). Third, there is a positive correlation between lactate levels prior to an anaerobic test and the ventilatory response developed by subjects at high altitude (R2=0.33, slope=-41.7, p<0.05). Lastly, this ventilatory response can influence the VO2peak (R2=0.60, slope=0.02, p<0.001). Conclusion: This study provides insights into the mechanisms behind the reduced respiratory capacity observed in women during an anaerobic exercise test at high altitude. Acute response to HA showed a greater work of breathing and increased drive ventilatory response. It is possible to postulate differences in the fatigue-induced metaborreflex of the respiratory muscles and aerobic-anaerobic transition between gender. These results on multiple sprints performance and the influences of gender in hypoxic environments deserve further investigation.This publication has 26 references indexed in Scilit:
- Resting and exercise ventilatory chemosensitivity across the menstrual cycleJournal of Applied Physiology, 2012
- Metabolic benefits of resistance training and fast glycolytic skeletal muscleAmerican Journal of Physiology-Endocrinology and Metabolism, 2011
- Clinician’s Guide to Cardiopulmonary Exercise Testing in AdultsJournal of the American College of Cardiology, 2010
- Arterial Blood Gases and Oxygen Content in Climbers on Mount EverestThe New England Journal of Medicine, 2009
- The human side of hypoxia‐inducible factorBritish Journal of Haematology, 2008
- Physiological Responses to Exercise at AltitudeSports Medicine, 2008
- Insights into the role of the respiratory muscle metaboreflexJournal Of Physiology-London, 2007
- Two routes to functional adaptation: Tibetan and Andean high-altitude nativesProceedings of the National Academy of Sciences of the United States of America, 2007
- Consequences of exercise-induced respiratory muscle workRespiratory Physiology & Neurobiology, 2006
- Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1Online Journal of Public Health Informatics, 1996