HLA Allele–Restricted Immune-Mediated Adverse Drug Reactions: Framework for Genetic Prediction
- 6 January 2022
- journal article
- review article
- Published by Annual Reviews in Annual Review of Pharmacology and Toxicology
- Vol. 62 (1), 509-529
- https://doi.org/10.1146/annurev-pharmtox-052120-014115
Abstract
Human leukocyte antigen (HLA) is a hallmark genetic marker for the prediction of certain immune-mediated adverse drug reactions (ADRs). Numerous basic and clinical research studies have provided the evidence base to push forward the clinical implementation of HLA testing for the prevention of such ADRs in susceptible patients. This review explores current translational progress in using HLA as a key susceptibility factor for immune ADRs and highlights gaps in our knowledge. Furthermore, relevant findings of HLA-mediated drug-specific T cell activation are covered, focusing on cellular approaches to link genetic associations to drug-HLA binding as a complementary approach to understand disease pathogenesis. Expected final online publication date for the Annual Review of Pharmacology and Toxicology, Volume 62 is January 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.Keywords
This publication has 100 references indexed in Scilit:
- Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivativesJournal of Allergy and Clinical Immunology, 2013
- The structural basis of HLA‐associated drug hypersensitivity syndromesImmunological Reviews, 2012
- Nonimmediate β-lactam reactions in patients with cystic fibrosisCurrent Opinion in Allergy and Clinical Immunology, 2012
- Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoireProceedings of the National Academy of Sciences of the United States of America, 2012
- Rarity of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibodies in statin users, including those with self-limited musculoskeletal side effectsArthritis Care & Research, 2011
- Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I and II AllelesGastroenterology, 2011
- Toxicogenomics of nevirapine-associated cutaneous and hepatic adverse events among populations of African, Asian, and European descentAIDS, 2011
- HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in EuropeansThe New England Journal of Medicine, 2011
- HLA-B*5701 Screening for Hypersensitivity to AbacavirThe New England Journal of Medicine, 2008
- Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactionsPharmacogenetics and Genomics, 2006