New Search

Export article

Asymmetric Synthesis of Enantiopure Pyrrolidines by C(sp 3 )−H Amination of Hydrocarbons

Yanis Lazib, Pascal Retailleau, Tanguy Saget, ,
Published: 30 July 2021

Abstract: The asymmetric synthesis of enantiopure pyrrolidines is reported via a streamlined strategy relying on two sequential C–H functionalizations of simple hydrocarbons. The first step is a regio- and stereoselective catalytic nitrene C–H insertion. Then, a subsequent diastereoselective cyclization involving a 1,5-Hydrogen Atom Transfer (HAT) from a N -centered radical leads to the formation of pyrrolidines that can then be converted to their free NH- derivatives.
Keywords: Pyrrolidine / C—H Amination / Nitrene / Haloamine / Stereoselectivity

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

Share this article

Click here to see the statistics on "Angewandte Chemie" .
References (98)
    Back to Top Top