Abstract: Development and use of nuclear energy is currently growing very rapidly, in order to achieve increasingly advanced technology, both in terms of design, economic factors and safety factors. Thermal-hydraulics aspects of nuclear reactors should be done with calculation and near-perfect condition. Including today began development of a nuclear reactor with low power below 300 MW, or commonly called the Small Modular Reactor (SMR). One is CAREM-25 developed by Argentina with a power of 25 MW, where in CAREM already using natural circulation system and the use of nanofluid as coolant fluid. In this research, analytic modeling of thermal-hydraulics nuclear reactor SMR CAREM-25, when the nanofluid Al2O3-Water used as cooling fluid in the cooling system of a nuclear reactor. Further to this analytic modeling will be done on CFD. Analytic modeling with CFD to determine the flow phenomena and distribution as well as the effect of nano-particles of Al2O3-Water based on the volume fraction (1% and 3%) of the coefficient of heat transfer by natural convection.