Synthesis and biological activity of functionalized phosphorus derivatives of isatin imines
Open Access
- 31 December 2011
- journal article
- Published by European Journal of Chemistry in European Journal of Chemistry
- Vol. 2 (4), 539-543
- https://doi.org/10.5155/eurjchem.2.4.539-543.55
Abstract
Isatin-3-imine derivatives (1a-d) have been synthesized. These compounds were then converted into phosphorylated products 2a, 2c with triethylphosphite and 3a-d with triphenylphosphine. The structures of the new compounds were confirmed by elemental analyses, IR, UV/VIS, 1H NMR, 13C NMR and MS studies. The structure of compound 1a was also confirmed by single crystal X-ray diffraction studies. Compounds 1b-d and 3c-d exhibited potent antibacterial activity against Bacillus subtilis and Escherichia Coli. Compound 3a was found to exhibit antifungal activity against the tested organisms.Keywords
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