Entangled radicals may explain lithium effects on hyperactivity
Open Access
- 9 June 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 11 (1), 1-10
- https://doi.org/10.1038/s41598-021-91388-9
Abstract
It is known that bipolar disorder and its lithium treatment involve the modulation of oxidative stress. Moreover, it has been observed that lithium’s effects are isotope-dependent. Based on these findings, here we propose that lithium exerts its effects by influencing the recombination dynamics of a naturally occurring radical pair involving oxygen. We develop a simple model inspired by the radical-pair mechanism in cryptochrome in the context of avian magnetoreception and xenon-induced anesthesia. Our model reproduces the observed isotopic dependence in the lithium treatment of hyperactivity in rats. It predicts a magnetic-field dependence of the effectiveness of lithium, which provides one potential experimental test of our hypothesis. Our findings show that Nature might harness quantum entanglement for the brain’s cognitive processes.Funding Information
- Natural Sciences and Engineering Research Council of Canada
This publication has 104 references indexed in Scilit:
- Magnetically sensitive light-induced reactions in cryptochrome are consistent with its proposed role as a magnetoreceptorProceedings of the National Academy of Sciences of the United States of America, 2012
- Lithium Impacts on the Amplitude and Period of the Molecular Circadian ClockworkPLOS ONE, 2012
- Light-activated Cryptochrome Reacts with Molecular Oxygen to Form a Flavin–Superoxide Radical Pair Consistent with MagnetoreceptionOnline Journal of Public Health Informatics, 2011
- Mitochondrial dysfunction and pathology in bipolar disorder and schizophreniaInternational Journal of Developmental Neuroscience, 2011
- CRY2 Is Associated with DepressionPLOS ONE, 2010
- Effect of sunlight exposure on cognitive function among depressed and non-depressed participants: a REGARDS cross-sectional studyEnvironmental Health, 2009
- The role of lithium in the treatment of bipolar disorder: convergent evidence for neurotrophic effects as a unifying hypothesisBipolar Disorders, 2009
- Role of Exchange and Dipolar Interactions in the Radical Pair Model of the Avian Magnetic CompassBiophysical Journal, 2008
- Perspectives on the Efficacy of Antidepressants for Child and Adolescent DepressionPLoS Medicine, 2005
- Oxidative stress in Parkinson's diseaseAnnals of Neurology, 2003