Current status, complications and prospects of fecal microbiota transplantation therapy
Open Access
- 15 April 2021
- journal article
- Published by Heighten Science Publications Corporation in Archives of Pathology and Clinical Research
- Vol. 5 (1), 004-009
- https://doi.org/10.29328/journal.apcr.1001021
Abstract
Currently, the emergence of highly virulent mutants in Europe and the United States has caused refractory recurrent Clostridium difficile infection (RCDI) to be a problem in clinical practice. In 2013, the Netherland group demonstrated breakthrough therapeutic efficacy in fecal microbial transplant (FMT) treatment clinical trials for RCDI, and FMT treatment is rapidly gaining attention. In addition to RCDI, FMT treatment has been attempted in various gastrointestinal diseases such as inflammatory bowel disease, irritable bowel syndrome and chronic constipation, as well as extragastrointestinal diseases. In this review, I would like to describe the current status, complications and prospects of FMT treatment.Keywords
This publication has 40 references indexed in Scilit:
- Fecal Microbiota Transplantation Induces Remission in Patients With Active Ulcerative Colitis in a Randomized Controlled TrialGastroenterology, 2015
- Findings From a Randomized Controlled Trial of Fecal Transplantation for Patients With Ulcerative ColitisGastroenterology, 2015
- Fecal Microbiota Transplantation for Clostridium difficile InfectionAnnals of Internal Medicine, 2015
- Oral, Capsulized, Frozen Fecal Microbiota Transplantation for RelapsingClostridium difficileInfectionJAMA, 2014
- Human Genetics Shape the Gut MicrobiomeCell, 2014
- Guidance on Preparing an Investigational New Drug Application for Fecal Microbiota Transplantation StudiesClinical Gastroenterology and Hepatology, 2013
- Duodenal Infusion of Donor Feces for RecurrentClostridium difficileThe New England Journal of Medicine, 2013
- Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic SyndromeGastroenterology, 2012
- Treating Clostridium difficile Infection With Fecal Microbiota TransplantationClinical Gastroenterology and Hepatology, 2011
- Clostridium difficile Infection Caused by the Epidemic BI/NAP1/027 StrainGastroenterology, 2009