Thermal Decomposition Kinetics of Ursodeoxycholic Acid Drug Crystal
Open Access
- 1 January 2017
- journal article
- Published by Scientific Research Publishing, Inc. in Journal of Crystallization Process and Technology
- Vol. 07 (04), 85-90
- https://doi.org/10.4236/jcpt.2017.74006
Abstract
The crystallization of ursodeoxycholic acid drug crystals in gel by reduction of solubility method is the first of its kind to be reported in literature. Monoclinic crystalline form of the structure was confirmed using single crystal X-ray diffraction analysis. This report deals with the kinetic analysis made from the thermogravimetric analysis/differential thermal analysis (TGA/DTA) data using Coats-Redfern (CR) relation. Thermodynamic parameters were also determined. Arrhenius equation for ursodeoxycholic acid was derived as k = 3.10 × 1010 e−172581/RT mol−1•s−1.Keywords
This publication has 1 reference indexed in Scilit:
- Kinetic Parameters from Thermogravimetric DataNature, 1964