Anti-glycation and anti-inflammatory activities of anthocyanins from purple vegetables
- 28 January 2023
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Food & Function
- Vol. 14 (4), 2034-2044
- https://doi.org/10.1039/d2fo03645b
Abstract
Anthocyanins may be effective bioactive constituents to reduce the potential risk of chronic diseases induced by glycation and inflammation. In the present study, the anti-glycation and anti-inflammatory activities of anthocyanins derived from purple cabbage (PCA), purple sweet potato (PSP), purple corn (PCO) and gynura bicolor (GB) were evaluated. According to the results from the bovine serum albumin (BSA)–fructose and BSA–methylglyoxal (MGO) model, the inhibition effects of anthocyanins on non-enzymatic glycosylation not only acted on the intermediate stage, but also played a certain role in the entire non-enzymatic glycosylation process, among which anthocyanins from PCA exhibited the best inhibitory effect. The anthocyanins from all four purple vegetables could trap MGO effectively (p > 0.05). The anthocyanins also presented a good inhibitory effect on amyloid beta peptide (Aβ)1–42 fibrillation, even better than that of aminoguanidine (AG), in a thermal induction assay. Furthermore, anthocyanins from PCA, PSP, PCO and GB showed significant anti-inflammatory effects, inhibiting pro-inflammatory factor (i.e., NO and TNF-α) production, among which the anthocyanins from PCA and PSP exhibited a higher inhibition effect than the others. This is probably due to the suppression of the TLR4-mediated MyD88 signaling pathway in the lipopolysaccharide (LPS)-induced BV2 cells based on the western blot analysis. Anthocyanins from purple vegetables could be used as a value-added food ingredient for the food industry. Food fortification with anthocyanins might be a promising way to protect humans against various chronic diseases caused by glycation and inflammation.Keywords
Funding Information
- National Key Research and Development Program of China (2019YFE0103900)
- Jiangsu Agricultural Science and Technology Innovation Fund (cx (22) 3163)
- Earmarked Fund for China Agriculture Research System (CARS-28)
This publication has 47 references indexed in Scilit:
- Protective ability of phenolics from white grape vinification by-products against structural damage of bovine serum albumin induced by glycationFood Chemistry, 2014
- Structure–activity relationships of anthocyanidin glycosylationMolecular Diversity, 2014
- Anthocyanins in blackcurrant effectively prevent the formation of advanced glycation end products by trapping methylglyoxalJournal of Functional Foods, 2014
- Glycation exacerbates the neuronal toxicity of β-amyloidCell Death & Disease, 2013
- Anthocyanins Downregulate Lipopolysaccharide-Induced Inflammatory Responses in BV2 Microglial Cells by Suppressing the NF-κB and Akt/MAPKs Signaling PathwaysInternational Journal of Molecular Sciences, 2013
- Serum concentration of an inflammatory glycotoxin, methylglyoxal, is associated with increased cognitive decline in elderly individualsMechanisms of Ageing and Development, 2011
- Phytochemicals from berries and grapes inhibited the formation of advanced glycation end‐products by scavenging reactive carbonylsFood Research International, 2011
- Advanced glycation endproducts and their receptor RAGE in Alzheimer's diseaseNeurobiology of Aging, 2011
- Antioxidant Activity of Anthocyanins and Their AglyconsJournal of Agricultural and Food Chemistry, 2003
- Amyloid β-peptide (1-42)-induced Oxidative Stress and Neurotoxicity: Implications for Neurodegeneration in Alzheimer's Disease Brain. A ReviewFree Radical Research, 2002