Clinical and immunological features and prognosis of different phenotypes of occupational asthma
- 1 September 2021
- journal article
- Published by FSBI Research Institute of Occupational Health RAMS in Occupational Health and Industrial Ecology
- Vol. 61 (7), 436-441
- https://doi.org/10.31089/1026-9428-2021-61-7-436-441
Abstract
Introduction. Occupational asthma is a complex and heterogeneous disease. Development of personalized treatment and prevention tactics becomes feasible due to phenotyping, which means identifying of markers to combine cases of occupational asthma with similar manifestations (clinical, instrumental, laboratory) and prognosis to phenotypes. The study aims to determination and comparative analysis of spirographic and immunological parameters for different phenotypes of occupational asthma. Materials and methods. In this study, we included 170 patients with different phenotypes of occupational asthma and 50 participants in control group. The spirographic examination was performed using computer spirograph with determination of the following parameters: forced vital capacity (FVC), forced expiratory volume during the first second (FEV1), Tiffeneau-Pinelli index (FEV1/FVC), peak expiratory flow (PEF), maximal expiratory flow at 75%, 50%, 25% of the forced vital capacity (MEF75%VC, MEF50%VC, MEF25%VC). Quantification of the immunoglobulins IgA, IgM, and IgG in human serum was conducted by Mancini method; levels of IgE, C-reactive protein and fibronectin were determined using a solid-phase enzyme immunoassay. Fibrinogen concentration in plasma was measured by an automatic coagulometer. Haptoglobin concentration in serum was determined by spectrophotometry. Results. According to spirometry and laboratory results obtained, there is a strong evidence, that the phenotype "occupational asthma - occupational chronic obstructive pulmonary disease" has the lowest values in pulmonary function tests and the most significant changes in immunoglobulins, fibronectin and acute phase proteins levels among other studied phenotypes of occupational asthma. Conclusions. Dynamic determination of spirometric, immunological parameters, fibronectin and proteins of the acute phase of inflammation in workers at risk for the formation of occupational bronchial asthma may be recommended to be carried out once every 6 months, followed by the isolation of disease phenotypes. This will optimize diagnostics, therapeutic and preventive tactics, as well as predict the course of this pathology.Keywords
This publication has 6 references indexed in Scilit:
- Occupational asthmaThe International Journal of Tuberculosis and Lung Disease, 2020
- Diagnosing occupational asthmaClinical & Experimental Allergy, 2016
- BRONCHIAL ASTHMA. WHAT IS IT POSSIBLE TO DO FOR ACHIEVEMENT OF CONTROL OF THIS DISEASE?Russian Journal of Allergy, 2012
- Pathogenesis of occupational asthma.European Respiratory Journal, 2003
- Differential diagnosis of occupational asthmaImmunology and Allergy Clinics of North America, 2003
- Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctionsJCI Insight, 1999