Stem cells and exosomes: promising candidates for necrotizing enterocolitis therapy
Open Access
- 5 June 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Stem Cell Research & Therapy
- Vol. 12 (1), 1-14
- https://doi.org/10.1186/s13287-021-02389-4
Abstract
Necrotizing enterocolitis (NEC) is a devastating disease predominately affecting neonates. Despite therapeutic advances, NEC remains the leading cause of mortality due to gastrointestinal conditions in neonates. Stem cells have been exploited in various diseases, and the application of different types of stem cells in the NEC therapy is explored in the past decade. However, stem cell transplantation possesses several deficiencies, and exosomes are considered potent alternatives. Exosomes, especially those derived from stem cells and breast milk, demonstrate beneficial effects for NEC both in vivo and in vitro and emerge as promising options for clinical practice. In this review, the function and therapeutic effects of stem cells and exosomes for NEC are investigated and summarized, which provide insights for the development and application of novel therapeutic strategies in pediatric diseases. Further elucidation of mechanisms, improvement in preparation, bioengineering, and administration, as well as rigorous clinical trials are warranted.Keywords
Funding Information
- National Natural Science Foundation of China (81300279, 81741067)
This publication has 67 references indexed in Scilit:
- Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunitiesNature Communications, 2020
- Remote ischemic conditioning counteracts the intestinal damage of necrotizing enterocolitis by improving intestinal microcirculationNature Communications, 2020
- The association of pregestational and gestational diabetes with severe neonatal morbidity and mortalityJournal of Perinatology, 2019
- Impaired Wnt/β-catenin pathway leads to dysfunction of intestinal regeneration during necrotizing enterocolitisCell Death & Disease, 2019
- Human Fetal TNF-α-Cytokine-Producing CD4+ Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in LifeImmunity, 2019
- Toll-Like Receptor–Mediated Intestinal Inflammatory Imbalance in the Pathogenesis of Necrotizing EnterocolitisCellular and Molecular Gastroenterology and Hepatology, 2018
- Pathogenesis of NEC: Role of the innate and adaptive immune responseSeminars in Perinatology, 2017
- Trends in Care Practices, Morbidity, and Mortality of Extremely Preterm Neonates, 1993-2012JAMA, 2015
- Biology of stem cells: an overviewKidney International Supplements, 2011
- Characteristics of patients who die of necrotizing enterocolitisJournal of Perinatology, 2011