Anticancer activity studies of some cyclic benzimidazole derivatives
Open Access
- 30 September 2012
- journal article
- Published by European Journal of Chemistry in European Journal of Chemistry
- Vol. 3 (3), 356-358
- https://doi.org/10.5155/eurjchem.3.3.356-358.621
Abstract
New benzimidazole derivatives, namely, (N-(4-methoxyphenyl)methylene]-1H-benzimidazol-2-amine (2a), (N-(3,4-dimethoxyphenyl)methylene]-1H-benzimidazol-2-amine (2b), and (N-(3,4,5-trimethoxyphenyl)methylene]-1H-benzimidazol-2-amine (2c) were synthesized by reaction of a Schiff base with malononitrile in absolute ethanol. Structures of compounds have been confirmed by IR, 1H NMR and elemental analysis. Compounds 2a-c were screened for their in vitro anticancer potential using HeLa and PC3 cells. All compounds showed limited cytotoxicity except compound 2a that showed a moderate cytotoxic effect towards HeLa cells.Keywords
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