Presepsin, Procalcitonin and C Reactive Protein as Diagnostic Biomarkers of Sepsis in Intensive Care Unit Patients

Abstract

Background: Sepsis is a global, life-threatening health priority. Blood culture is the gold standard of diagnosis sepsis; however, it requires several days, which delays the diagnosis of the sepsis. Biomarkers could play a pivotal role in diagnosis, grading and predicting the outcome of sepsis. Objectives: were to assess the potential role of CRP, PCT and presepsin for diagnosis, grading and predict the prognosis of sepsis.Patients and methods: The study included 58 patients, 28 patients diagnosed with sepsis, and 28 ICU patients presented by different presentation but with no sepsis. For patients with sepsis, APACHE II score was calculated, Blood culture was done using BacT/Alert system, and Vitek 2 to identify bacterial isolates. For all subjects included in the study, quantitative measurement of CRP, PTC and presepsin were done using PA54 Specific Protein Analyzer, VIDAS® immune-analyzer, and PATHFAST fully automated immunoassay analyzer respectively.Results: APACHE II score positively correlated with PCT (p=0.026) and presepsin (p=0.034), but not CRP (p=0.291). Differences between cases and control group for the three biomarkers’ levels) were statistically significant (P value