Morphological Changes Induced by Bipolar Radiofrequency Ablation in Thyroid Nodules – a Preclinical Ex Vivo Investigation
Open Access
- 1 January 2016
- journal article
- Published by Touch Medical Media, Ltd. in touchREVIEWS in Endocrinology
- Vol. 12 (2), 85-88
- https://doi.org/10.17925/EE.2016.12.02.85
Abstract
Introduction: Recently, radiofrequency ablation (RFA) has been increasingly used for the treatment of thyroid nodules. However, immediate morphological changes associated with bipolar devices are poorly shown. Aims: To present the results of analysis of gross and microscopic alterations in human thyroid tissue induced by RFA delivered through the application of the original patented device. Materials and methods: In total, there were 37 surgically removed thyroid glands in females aged 32–67 at presentation: 16 nodules were follicular adenoma (labelled as ‘parenchymal’ solid benign nodules) and adenomatous colloid goitre was represented by 21 cases. The thyroid gland was routinely processed and the nodules were sliced into two parts – one was a subject for histological routine processing according to the principles that universally apply in surgical pathology, the other one was used for the RFA procedure. Results: No significant difference in size reduction between parenchymal and colloid nodules was revealed (p>0.1, t-test) straight after the treatment. In addition, RFA equally effectively induced necrosis in follicular adenoma and adenomatous colloid goitre (p>0.1, analysis of variance test). As expected, tumour size correlated with size reduction (the smaller the size of the nodule, the greater percentage of the nodule volume that was ablated): r=−0.48 (pex vivoexperiments to clinical practice.Keywords
This publication has 19 references indexed in Scilit:
- Radiofrequency ablation for treatment of benign thyroid nodules: Systematic reviewThe Laryngoscope, 2013
- Radiofrequency Ablation of Benign Thyroid Nodules and Recurrent Thyroid Cancers: Consensus Statement and RecommendationsKorean Journal of Radiology, 2012
- Bipolar Radiofrequency Ablation for Nodular Thyroid Disease—Ex Vivo and In Vivo Evaluation of a Dose-Response RelationshipJournal of Surgical Research, 2011
- Thermal Ablation for Benign Thyroid Nodules: Radiofrequency and LaserKorean Journal of Radiology, 2011
- Non-malignant Thyroid Diseases after a Wide Range of Radiation ExposuresRadiation Research, 2010
- Very high prevalence of thyroid nodules detected by high frequency (13 MHz) ultrasound examinationEuropean Journal of Clinical Investigation, 2009
- Uncovering a Rare but Critical Complication Following Thyroid Surgery: An Audit Across the UK and IrelandThyroid®, 2007
- Prevalence and Distribution of Carcinoma in Patients with Solitary and Multiple Thyroid Nodules on SonographyJournal of Clinical Endocrinology & Metabolism, 2006
- Radiofrequency Ablation and Percutaneous Ethanol Injection Treatment for Recurrent Local and Distant Well-Differentiated Thyroid CarcinomaAnnals of Surgery, 2006
- Radiofrequency Ablation of Benign Cold Thyroid Nodules: Initial Clinical ExperienceThyroid®, 2006