Protective effect of Alsidium corallinum against TNF-α toxicity in H9c2 cells

Abstract

Sepsis is a principal cause of human mortality. Tumor necrosis factor alpha (TNF-α) is a factor of the myocardial dysfunction induced by sepsis. The present study attempts to determine the role of the macroalga Alsidium corallinum (A. corallinum) from TNF-α-induced sepsis. The cardiomyocytes H9c2 exposed to A. corallinum extract, then these cells have treated with TNF-α. H9c2 viability and antioxidant defense like glutathione peroxidase, superoxide dismutase, catalase and glutathione were evaluated. Main results reported that TNF-α caused a morphological cell modifications and, a reduction in H9c2 viability, and an increase of antioxidant defense. A. corallinum-treatment reduced the toxicity induced by TNF-α. These results demonstrated the cytoprotector role of A. corallinum against oxidative stress.