Synthesis and Antimicrobial Activity of New Pyridine Containing Substituted Phenyl Azetidine-2-One Derivatives
Open Access
- 1 January 2018
- journal article
- research article
- Published by Scientific Research Publishing, Inc. in Open Journal of Medicinal Chemistry
- Vol. 08 (02), 22-29
- https://doi.org/10.4236/ojmc.2018.82003
Abstract
The most important nitrogen containing heterocycles of pyridine containing substituted phenyl azetidine-2-ones have found pharmacological application such as antibiotics and these compounds also have practical importance. The structure of the new derivatives was confirmed by the spectral data and elemental analyses. Out of five new derivatives, three were revealed mild to moderate activity compared with Streptomycin & Fluconazole as a reference standard. Among this new series, 3-chloro-1-(4-fluoro phenyl)/(4-chloro phe-nyl)-4-(pyridine-3-yl) azetidine-2-one (4a & b) were found most activity.Keywords
This publication has 11 references indexed in Scilit:
- 1Synthesis and QSAR analysis of 5-substituted (arylmethylene) pyridin-2-amine derivatives as potential antibacterialsInternational Journal of Drug Discovery, 2009
- Green route for the heterocyclization of 2-mercaptobenzimidazole into β-lactum segment derivatives containing –CONH– bridge with benzimidazole: Screening in vitro antimicrobial activity with various microorganismsBioorganic & Medicinal Chemistry, 2006
- Anticancer activities of some newly synthesized pyridine, pyrane, and pyrimidine derivativesBioorganic & Medicinal Chemistry, 2006
- Novel Approach for the Rapid and Efficient Synthesis of Heterocyclic Schiff Bases (III) and Azetidinones (V) under Microwave Irradiation.ChemInform, 2006
- Facile Synthesis of Some New Azetidinones (VI) and Acetyl Oxadiazoles (VIII) Bearing Benzo[b]thiophene Nucleus as a Potent Biological Active Agent.ChemInform, 2005
- Synthesis and antibacterial activity of some Schiff bases derived from 4-aminobenzoic acidJournal of the Serbian Chemical Society, 2005
- Synthesis of Some Biologically Active Pyrazole, Thiazolidinone, and Azetidinone DerivativesChemistry of Heterocyclic Compounds, 2004
- Well diffusion for antifungal susceptibility testingInternational Journal of Infectious Diseases, 2004
- Dinuclear Alkyldiamine Platinum Antitumor Compounds: A Structure−Activity Relationship StudyJournal of Medicinal Chemistry, 2000
- 4-Aminoquinolines: Novel Nociceptin Antagonists with Analgesic ActivityJournal of Medicinal Chemistry, 2000