Assessment of lead toxicity on locomotion and growth in a nematode Caenorhabditis elegans
Open Access
- 15 March 2020
- journal article
- Published by ANSF Publications in Journal of Applied and Natural Science
- Vol. 12 (1), 36-41
- https://doi.org/10.31018/jans.v12i1.2227
Abstract
Due to anthropogenic activities and natural abundance, lead exposure is a common phenomenon. Neurotoxic and genotoxic effects of lead are widely known. Recent studies have suggested that lead exposure can affect young generation and transfer to the progeny thus posing a great threat for future generation. The present study was focused on lead toxicity in terms of locomotion and growth of Caenorhabditis elegans (N2 wild type) at three sub-lethal doses (3µM, 15 µM and 30 µM) of Pb (NO3)2 for 24 hours (sub-chronic exposure). Caenorhabditis elegans is a nematode with an established eco- toxicity marker model organism, due to its short life cycle and ease to monitor. After lead exposure, significant toxic manifestations were observed in locomotion of the nematode in terms of omega bends (+350% for 30 µM exposure dose, pC. elegans.This publication has 30 references indexed in Scilit:
- Optimizing Pharmacological Lifespan ExtensionPublished by Dominican University of California ,2019
- Lead induces inflammation and neurodegenerative changes in the rat medial prefrontal cortexAnatomy, 2017
- Advanced Behavioral Analyses Show that the Presence of Food Causes Subtle Changes in C. elegans MovementFrontiers in Behavioral Neuroscience, 2016
- Caenorhabditis elegans as a Biological Model for Multilevel Biomarker Analysis in Environmental Toxicology and Risk AssessmentToxicological Research, 2008
- Assessment of locomotion behavioral defects induced by acute toxicity from heavy metal exposure in nematode Caenorhabditis elegansJournal of Environmental Sciences, 2008
- Chronic Lead Exposure May be Associated with Erectile DysfunctionThe Journal of Sexual Medicine, 2007
- BehaviorWormBook, 2006
- ASSESSMENT OF SUBLETHAL ENDPOINTS FOR TOXICITY TESTING WITH THE NEMATODE CAENORHABDITIS ELEGANSEnvironmental Toxicology and Chemistry, 2001
- Chapter 1 Basic Culture MethodsMethods in Cell Biology, 1995
- THE GENETICS OF CAENORHABDITIS ELEGANSGenetics, 1974