One-Step Three-Component Synthesis of New 2,5,6,7-Functionalized 5,8-Dihydropyrido-[2,3-d]pyrimidin-4(3H)-ones
- 1 January 2018
- journal article
- research article
- Published by Pleiades Publishing Ltd in Russian Journal of Organic Chemistry
- Vol. 54 (1), 107-111
- https://doi.org/10.1134/s1070428018010104
Abstract
One-step three-component cyclocondensation of 2,6-disubstituted pyrimidin-4(3H)-ones with 1,3-dicarbonyl compounds and some aromatic and heterocyclic aldehydes on heating or under microwave irradiation afforded new functionally substituted 5,8-dihydropyrido[2,3-d]pyrimidin-4(3H)-ones. Conventional heating was found to be more advantageous. The effects of the 2-substituent in the initial pyrimidin-4(3H)-one and the nature of the dicarbonyl component on the product structure and yield were analyzed.Keywords
This publication has 9 references indexed in Scilit:
- Annulation of 6-aminouracils with 2,3-dimethoxy- and 2-fluorobenzaldehydes and 2-chloro-7-methoxyquinoline-3-carbaldehydeRussian Journal of Organic Chemistry, 2015
- Synthesis and X-ray analysis of some pyrido[2,3-d]pyrimidinesRussian Journal of Organic Chemistry, 2014
- Synthesis and antifungal activity of some new pyrido[2,3-d]pyrimidinesEuropean Journal of Chemistry, 2011
- Synthesis of new 2-substituted pyrido[2,3-d]pyrimidin-4(1H)-ones and their antibacterial activityEuropean Journal of Medicinal Chemistry, 2009
- Microwave-assisted one-pot synthesis of 2-amino-6,7-disubstituted-5-methyl-5,8-dihydropyrido[2,3-d]pyrimidin-4(3H)-one without catalystArkivoc, 2005
- A three-component synthesis of pyrido[2,3-d]pyrimidinesTetrahedron Letters, 2003
- Pyrido [2, 3-d]pyrimidines and Pyrimido[5′, 4′:5, 6]pyrido[2, 3-d]pyrimidines as New Antiviral Agents: Synthesis and Biological ActivityArchiv der Pharmazie, 2002
- Syntheses of 7-Alkyl-1,3,6-trimethylpyrrolo(2,3-d)pyrimidines and 4-Alkylamino-2,5-dimethyl-2,3-dihydrofuro(3,2-e)pyrimidines.CHEMICAL & PHARMACEUTICAL BULLETIN, 1992
- The content of 5-methylcytosine in animal DNA: The species and tissue specificityBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1973