One‐Pot Tandem Michael Addition/Enantioselective Conia‐Ene Cyclization Mediated by Chiral Iron(III)/Silver(I) Cooperative Catalysis
- 5 June 2020
- journal article
- research article
- Published by Wiley in Angewandte Chemie
- Vol. 59 (38), 16470-16474
- https://doi.org/10.1002/anie.202007180
Abstract
The first one-pot tandem Michael addition/enantioselective Conia-ene cyclization of N-protected prop-2-yn-1-amines with 2-methylene-3-oxoalkanoates promoted by chiral iron(III)/silver(I) cooperative catalysts has been developed. Alkyl 4-methylenepyrrolidine-3-acyl-3-carboxylates, which can be transformed into β-proline derivatives, are obtained in high yield with high enantioselectivity.Funding Information
- Japan Society for the Promotion of Science (15H05755, 15H06266, 17K14484, 15H05810)
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