Currently, there is a debate among feline clinicians about the efficacy and safety of modified live virus vaccination in cats infected with retroviruses: feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV). In clinical routine, the serological status of all patients with regard to feline retroviruses should be known, which ends up not occurring due to financial reasons of the client or the non-referral of the test by the veterinarian. In practice, it is observed that FIV and FeLV positive cats are vaccinated with attenuated vaccines, without showing any clinical signs of immunosuppression or side effects. This work reviews cat vaccination against these retroviruses.