Addressing the treatment of macrophage activation syndrome: A challenging balance between immune suppression and infectious risk
- 13 August 2022
- journal article
- Published by Peertechz Publications Private Limited in Global Journal of Infectious Diseases and Clinical Research
- Vol. 8 (1), 011-014
- https://doi.org/10.17352/2455-5363.000052
Abstract
Hemophagocytic Lymphohistiocytosis (HLH) is a rare and potentially life-threatening syndrome related to a dysregulation of cytolytic function of Natural Killer (NK) cells and cytotoxic T cells (CTLs), which in turns leads to an inappropriate immune stimulation and hyperinflammatory state, resulting in hypercytokinemia, accumulation of activated lymphocytes and macrophages [1,2].Keywords
This publication has 11 references indexed in Scilit:
- Can we truly diagnose adult secondary hemophagocytic lymphohistiocytosis (HLH)? A critical review of current paradigmsPathology - Research and Practice, 2020
- Hemophagocytic lymphohistiocytosis in critically ill patients: diagnostic reliability of HLH-2004 criteria and HScoreCritical Care, 2020
- Recommendations for the management of hemophagocytic lymphohistiocytosis in adultsBlood, 2019
- The Immunology of Macrophage Activation SyndromeFrontiers in Immunology, 2019
- Macrophage activation syndrome in adults: recent advances in pathophysiology, diagnosis and treatmentRheumatology, 2018
- 2016 Classification Criteria for Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: A European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organisation Collaborative InitiativeArthritis & Rheumatology, 2016
- Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation SyndromeCritical Care Medicine, 2016
- Development and Validation of the HScore, a Score for the Diagnosis of Reactive Hemophagocytic SyndromeArthritis & Rheumatology, 2014
- HLH‐2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosisPediatric Blood & Cancer, 2006
- Efficacy of cyclosporine A in the treatment of macrophage activation syndrome in juvenile arthritis: Report of five casesThe Journal of Pediatrics, 1996