Allergy: Mechanistic insights into new methods of prevention and therapy
- 18 January 2023
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science Translational Medicine
- Vol. 15 (679), eadd2563
- https://doi.org/10.1126/scitranslmed.add2563
Abstract
In the past few decades, the prevalence of allergic diseases has increased worldwide. Here, we review the etiology and pathophysiology of allergic diseases, including the role of the epithelial barrier, the immune system, climate change, and pollutants. Our current understanding of the roles of early life and infancy; diverse diet; skin, respiratory, and gut barriers; and microbiome in building immune tolerance to common environmental allergens has led to changes in prevention guidelines. Recent developments on the mechanisms involved in allergic diseases have been translated to effective treatments, particularly in the past 5 years, with additional treatments now in advanced clinical trials.This publication has 121 references indexed in Scilit:
- Overview of atopic dermatitisAsia Pacific Allergy, 2013
- The possible influence of the environment on respiratory allergy: a survey on immigrants to ItalyAnnals of Allergy, Asthma & Immunology, 2011
- Eczema Prevalence in the United States: Data from the 2003 National Survey of Children's HealthJournal of Investigative Dermatology, 2011
- International variations in associations of allergic markers and diseases in children: ISAAC Phase TwoAllergy, 2010
- Total IgE levels and asthma prevalence in the US population: Results from the National Health and Nutrition Examination Survey 2005-2006Journal of Allergy and Clinical Immunology, 2009
- Immune Responses in Healthy and Allergic Individuals Are Characterized by a Fine Balance between Allergen-specific T Regulatory 1 and T Helper 2 CellsThe Journal of Experimental Medicine, 2004
- Systemic reactions to allergy skin testsAnnals of Allergy, Asthma & Immunology, 1999
- Role of interleukin 10 in specific immunotherapy.JCI Insight, 1998
- The distribution of total and specific serum IgE in the European Community Respiratory Health SurveyJournal of Allergy and Clinical Immunology, 1997
- Asthma and migrationRespirology, 1996