Introduction. The paper presents the research findings of investigating the problem of training healthcare leaders in the management of sustainable development. The purpose of the article is to analyze the international practice of training managers in various industries and to assess the effectiveness of using ‘Process Factory’ in the development of professional competencies related to quality management of healthcare settings. Materials and Methods. The study used general empirical and theoretical research methods, general logical methods and techniques, as well as methods of system analysis, comparison and analogy, and generalization. The key criterion for selecting research papers was focusing on the problems of training healthcare managers in the quality of medical care in the context of sustainable development management. In order to solve this problem, a business game called ‘Quality management of medical care’ based on the ‘Process Factory’ was developed. The empirical data were processed using a standard software package. Results. The authors have identified the following problems in the quality of training healthcare managers: low involvement in the educational process, denial of the best experiences, and an authoritarian management style. At the same time, the research has shown that managers need professional competencies in the field of analysis of multifactor processes, team management, projects, skills to integrate strategic development tasks into the current activities of the organization. The business game developed by the authors is based on the model of training in ‘learning factories’ as the foundation for training in lean manufacturing. Using the business game has led to the following outcomes: the interest of trainees increased by 9 times, involvement in the educational process-by 20 times, mastering skills – by 2 times, performing skills – by 8 times, readiness to apply the obtained skills – by 17 times. Conclusions. The article concludes that the constant implementation of changes in the healthcare system requires non-standard solutions from the leaders. The conducted educational experiment showed that the proposed educational technology makes it possible to model various situations in the learning environment. In the process of conducting a business game, the leader acquires competencies aimed at conflict management, encouragement of personnel, and receiving reliable information about the activities of the healthcare organization.