ABSTRAKSecara global dilaporkan 51.857 kasus konfimasi di 25 negara dengan 1.669 kematian (CFR 3,2%). Jumlah pasien positif Covid-19 di Provinsi NTB sampai tanggal (30/6/2020) sebanyak 1.245 orang, dengan perincian 825 orang sudah sembuh, 65 meninggal dunia, serta 355 orang masih positif dan dalam keadaan baik. Sedangkan jumlah pasien positif Covid-19 di Kota Mataram sebanyak 531 orang, dengan perincian 189 sedang dirawat, 310 orang sudah sembuh, 32 meninggal dunia. Tujuan pengabdian ini untuk mencegah penyebaran coronavirus (COV) di wilayah kerja Puskesmas Karang Pule Kegiatan penyuluhan ini menggunakan video cara Cuci Tangan Pakai Sabun (CTPS) Kemenkes dimana peserta pengabdian yang hadir berjumlah 20 orang. Kegiatan ini dilakukan dalam tiga tahap. Tahap pertama yakni pembagian kuesioner dan pemaparan, tahap kedua yakni Praktek Cuci Tagan Pakai Sabun dan tahap ketiga yakni tanya jawab serta pembagian kuesioner post test. Kegiatan pengabdian ini disambut sangat antusias, ibu melontarkan beberapa pertanyaan terkait Cuci Tangai Pakai Sabun dan pembuatan cairan disinfektan Sebagian besar ibu paham dengan penyuluhan yang diberikan. Penyuluhan ini dapat meningkatkan pengetahuan ibu dengan kategori pengetahuan baik sebesar 90 % (18 0rang) tentang Cuci Tangan Pakai Sabun (CTPS) untuk pencegahan coronavirus .Kata kunci: Penyuluhan; Cuci Tangan Pakai Sabun; Pencegahan Coronavirus. ABSTRACTGlobally, 51,857 confirmed cases were reported in 25 countries with 1,669 deaths (CFR 3.2%). The number of Covid-19 positive patients in NTB Province as of (6/30/2020) was 1,245 people, with details of 825 people recovered, 65 dead, and 355 people still positive and in good condition. While the number of positive patients Covid-19 in the city of Mataram was 531 people, with the details of 189 being treated, 310 people were cured, 32 died. The purpose of this service is to prevent the spread of coronavirus (COV) in the working area of Karang Pule Health Center. This counseling activity uses a video on how to wash hands with soap (CPTS) from the Ministry of Health where there are 20 community service attendees. This activity is carried out in three stages. The first stage is the distribution of questionnaires and exposure, the second stage is the Practice of Washing with Soap and the third stage is the question and answer session and the distribution of post test questionnaires. This service was welcomed with great enthusiasm, the mother asked a number of questions related to washing Tangai with soap Most of the mothers understood the counseling given. This counseling can increase the knowledge of mothers with good knowledge categories by 90% (18 people) about Handwashing with Soap (CTPS) for the prevention of coronavirus. Keywords: Counseling; hand washing behavior with soap; Coronavirus Prevention.