Rota virus that cause diarrhea and other diseases in small infants is belonging to a virus family called Reoviridae with death rate of about more than 200000 annually. Although many vaccines are available for Rotavirus infection but still primary reason of death among infants. To prevent infection caused by this virus as diarrhea and other gastroenteritis in piglets we use a resveratrol, a natural phenol and a phytoalexin with a potential of strong antibiotic and antiviral, which has preventive and protecting outcome against Rotavirus infection in piglets. Pretreatment done and resveratrol dry suspension added to the adequate essential nutrient (basal diet) and the animal through oral route done Rotavirus and then know about the outcome of resveratrol dry suspension. Therefore, our main concern is to use the resveratrol dry suspension, which produced immunity in piglets against Rotavirus. It has positive outcome and reduced the diarrhea and other gastroenteritis. Therefore, the outcome of resveratrol dry suspension shows that it could be the best one to treat the diarrhea and other disease, which caused by this virus.