Effect of dietary selenium intake on gut microbiota in older population in Enshi region
Open Access
- 13 December 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Genes and Environment
- Vol. 43 (1), 1-10
- https://doi.org/10.1186/s41021-021-00220-3
Abstract
The microbial ecosystem in the human gut varies between individuals with differences in diet. Selenium is one of most common trace elements in everyday diet, and selenium intake affects the human gut microbiota. We studied the effect of selenium intake on the gut microbiota in regions of Enshi with different distributions of selenium. One hundred elderly subjects (>65 years) were recruited from high-selenium and low-selenium areas in Enshi and blood, nail, and fecal specimens were obtained. The selenium contents in these samples were determined in triplicate by hydride generation atomic fluorescence spectrometry. DNA was extracted from fecal specimens and the microbial diversity was analyzed by 16 S RNA. The selenium contents in the blood and nails were significantly different between the high- and low-selenium areas, and the composition of the intestinal microbiota, including abundance and extent of intestinal flora, was altered. The function and metabolic pathways of the gut microbiota showed clear differences. As a trace element in human diet, selenium intake is an important factor that affects the intestinal microbiota and is likely involved in many human diseases. This study provides new clues and ideas for studying the correlation between selenium and human health.Keywords
Funding Information
- Enshi Prefecture Science and Technology Bureau Basic Research Project (XYJ2016000306)
This publication has 35 references indexed in Scilit:
- Gut microbiota and probiotics in colon tumorigenesisCancer Letters, 2011
- Has the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System?Science, 2010
- Commensal bacteria play a role in mating preference of Drosophila melanogasterProceedings of the National Academy of Sciences of the United States of America, 2010
- An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancerThe Journal of Experimental Medicine, 2010
- Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural AfricaProceedings of the National Academy of Sciences of the United States of America, 2010
- Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitisProceedings of the National Academy of Sciences of the United States of America, 2010
- QIIME allows analysis of high-throughput community sequencing dataNature Methods, 2010
- A core gut microbiome in obese and lean twinsNature, 2008
- Symbiotic gut microbes modulate human metabolic phenotypesProceedings of the National Academy of Sciences of the United States of America, 2008
- Metagenomic Analysis of the Human Distal Gut MicrobiomeScience, 2006