Reaction of imidazo[1,2-a]pyridines with coumarin-3-carboxylic acids: a domino Michael addition/decarboxylation/oxidation/annulation
- 4 October 2022
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in New Journal of Chemistry
- Vol. 46 (40), 19455-19459
- https://doi.org/10.1039/d2nj02706b
Abstract
A facile, metal- and additive-free C–C bond construction between imidazo[1,2-a]pyridines and coumarin-3-carboxylic acids through a decarboxylative Michael addition is reported to achieve an imidazo[1,2-a]pyridin-3-yl-chroman-2-one skeleton. In addition, heterocyclic polyaromatic dibenzoisochromenoimidazo[1,2-a]pyridin-6-ones of value for future medicinal chemistry can be obtained successfully by this procedure through a domino reaction involving Michael addition/decarboxylation/oxidation/C–H bond activation and annulation.Keywords
Funding Information
- University of Tehran (-)
- Iran National Science Foundation (99002277)
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