Ocrelizumab-induced Psoriasis in A Patient with Relapsing-Remitting Multiple Sclerosis
Open Access
- 30 April 2023
- journal article
- Published by European Open Science Publishing in European Journal of Biology and Biotechnology
- Vol. 5 (3), 1-2
- https://doi.org/10.24018/ejmed.2023.5.3.1697
Abstract
Background: Ocrelizumab is widely used as a Disease Modifying Drug (DMD) in Multiple sclerosis. The complete side effects are yet not known. Materials and Methods: We describe a 34-year-old female with longstanding relapsing-remitting Multiple Sclerosis for whom Ocrelizumab was started as an escalation therapy. She reported severe itchy and patchy lesions two months after the first full dose of Ocrelizumab. Pathohistological findings revealed the diagnosis of guttate psoriasis. Psoriasis continued to flare against treatment with topical steroids, and UV therapy and progressed to developed arthritis psoriasis. Results: Treatment escalated to an IL-17 antagonist (Secukinumab), with a favorable outcome. Ocrelizumab was discontinued. After one year of follow-up, the patient remained stable from an MS standpoint. Conclusion: This is the third report showing the possible cutaneous side effect of Ocrelizumab.Keywords
This publication has 9 references indexed in Scilit:
- Efficacy and Safety of Multiple Sclerosis Drugs Approved Since 2018 and Future DevelopmentsCNS Drugs, 2022
- Psoriasis caused by ocrelizumab in two persons with primary progressive multiple sclerosisInternational Journal of Dermatology, 2022
- Treatment approaches to patients with multiple sclerosis and coexisting autoimmune disordersTherapeutic Advances in Neurological Disorders, 2021
- Secukinumab for patients with plaque psoriasis affected by multiple sclerosis: a mini‐review with a representative case reportJournal of the European Academy of Dermatology and Venereology, 2019
- Does Natalizumab Induce or Aggravate Psoriasis? A Case Study and Review of the LiteratureCase Reports in Neurology, 2018
- Prevalence of psoriasis phenotypes among men and women in the USAClinical and Experimental Dermatology, 2016
- Risk of Multiple Sclerosis in Patients with Psoriasis: A Danish Nationwide Cohort StudyJournal of Investigative Dermatology, 2016
- Global Epidemiology of Psoriasis: A Systematic Review of Incidence and PrevalenceJournal of Investigative Dermatology, 2013
- Induced psoriasis after rituximab therapy for rheumatoid arthritis: a case report and review of the literatureRheumatology International, 2012