MicroRNAs: Important Regulatory Molecules in Acute Lung Injury/Acute Respiratory Distress Syndrome
Open Access
- 16 May 2022
- journal article
- review article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 23 (10), 5545
- https://doi.org/10.3390/ijms23105545
Abstract
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is an overactivated inflammatory response caused by direct or indirect injuries that destroy lung parenchymal cells and dramatically reduce lung function. Although some research progress has been made in recent years, the pathogenesis of ALI/ARDS remains unclear due to its heterogeneity and etiology. MicroRNAs (miRNAs), a type of small noncoding RNA, play a vital role in various diseases. In ALI/ARDS, miRNAs can regulate inflammatory and immune responses by targeting specific molecules. Regulation of miRNA expression can reduce damage and promote the recovery of ALI/ARDS. Consequently, miRNAs are considered as potential diagnostic indicators and therapeutic targets of ALI/ARDS. Given that inflammation plays an important role in the pathogenesis of ALI/ARDS, we review the miRNAs involved in the inflammatory process of ALI/ARDS to provide new ideas for the pathogenesis, clinical diagnosis, and treatment of ALI/ARDS.Funding Information
- Open Scientific Research Program of Military Logistics (BLB19J006, BLB20J009)
This publication has 138 references indexed in Scilit:
- SOCS3 Expression Correlates with Severity of Inflammation, Expression of Proinflammatory Cytokines, and Activation of STAT3 and p38 MAPK in LPS-Induced InflammationIn VivoMediators of Inflammation, 2013
- MicroRNA-181b regulates NF-κB–mediated vascular inflammationJCI Insight, 2012
- Regulation of ENaC-mediated alveolar fluid clearance by insulin via PI3K/Akt pathway in LPS-induced acute lung injuryRespiratory Research, 2012
- NF-κB, the first quarter-century: remarkable progress and outstanding questionsGenes & Development, 2012
- Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglyceridesNature, 2011
- Blast injuriesThe Lancet, 2009
- MicroRNAs: Target Recognition and Regulatory FunctionsCell, 2009
- MicroRNA-155 is induced during the macrophage inflammatory responseProceedings of the National Academy of Sciences of the United States of America, 2007
- TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencingNature, 2005
- Processing of primary microRNAs by the Microprocessor complexNature, 2004