Study on Enhanced Antibacterial and Cytotoxicity of Pure and Cadmium Doped Cerium Oxide against Gram-Positive and Gram-Negative Bacteria

Abstract

Pure and Cadmium (Cd) doped Cerium oxide nanoparticles (CeNPs) have been synthesised by the simple chemical co-precipitation technique. Cadmium ions of concentrations 1, 3 and 5 mol% were doped to investigate their influence on the structural and optical properties of CeO2. The synthesised samples have been subjected to X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray (EDX) analysis and high-resolution transmission electron microscopy (HRTEM). The XRD and Raman patterns have witnessed the cubic structure of the cerium oxide nanoparticles. The average particle size of CeO2 was found to be around 10 nm. SEM image has also ascertained that the grain size of pure CeO2 appeared is bigger than that of the Cd-doped, which intern indicates the grain growth upon doping. Besides, the antibacterial activity of the cadmium doped cerium oxide nanoparticles against some human pathogens revealed that they have exhibited the maximum zone of inhibition against gram-positive bacteria than the gram-negative species. Further, the cytotoxic effect of Cd-doped CeO2 sample is examined in cultured (MCF-7, A549 and Hep-2) cell.