Early Neuromuscular Blockade in Moderate-to-Severe Pediatric Acute Respiratory Distress Syndrome
- 6 January 2022
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Critical Care Medicine
- Vol. 50 (5), e445-e457
- https://doi.org/10.1097/ccm.0000000000005426
Abstract
Objectives: The use of neuromuscular blocking agents (NMBAs) in pediatric acute respiratory distress syndrome (PARDS) is common but unsupported by efficacy data. We sought to compare the outcomes between patients with moderate-to-severe PARDS receiving continuous NMBA during the first 48 hours of endotracheal intubation (early NMBA) and those without. Design: Secondary analysis of data from the Randomized Evaluation of Sedation Titration for Respiratory Failure (RESTORE) clinical trial, a pediatric multicenter cluster randomized trial of sedation. Setting: Thirty-one PICUs in the United States. Patients: Children 2 weeks to 17 years receiving invasive mechanical ventilation (MV) for moderate-to-severe PARDS (i.e., oxygenation index ≥ 8 and bilateral infiltrates on chest radiograph on days 0–1 of endotracheal intubation). Interventions: NMBA for the entire duration of days 1 and 2 after intubation. Measurements and Main Results: Among 1,182 RESTORE patients with moderate-to-severe PARDS, 196 (17%) received early NMBA for a median of 50.0% ventilator days (interquartile range, 33.3–60.7%). The propensity score model predicting the probability of receiving early NMBA included high-frequency oscillatory ventilation on days 0–2 (odds ratio [OR], 7.61; 95% CI, 4.75–12.21) and severe PARDS on days 0–1 (OR, 2.16; 95% CI, 1.50–3.12). After adjusting for risk category, early use of NMBA was associated with a longer duration of MV (hazard ratio, 0.57; 95% CI, 0.48–0.68; p < 0.0001), but not with mortality (OR, 1.62; 95% CI, 0.92–2.85; p = 0.096) compared with no early use of NMBA. Other outcomes including cognitive, functional, and physical impairment at 6 months post-PICU discharge were similar. Outcomes did not differ when comparing high versus low NMBA usage sites or when patients were stratified by baseline PaO2/FIO2 less than 150. Conclusions: Early NMBA use was associated with a longer duration of MV. This propensity score analysis underscores the need for a randomized controlled trial in pediatrics.This publication has 36 references indexed in Scilit:
- Mechanical Ventilation Strategies in Children With Acute Lung InjuryPediatric Critical Care Medicine, 2013
- Neuromuscular blocking agents in acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trialsCritical Care, 2013
- Acute lung injury in children: Therapeutic practice and feasibility of international clinical trials*Pediatric Critical Care Medicine, 2010
- Neuromuscular blocking agents decrease inflammatory response in patients presenting with acute respiratory distress syndrome*Critical Care Medicine, 2006
- Readers guide to critical appraisal of cohort studies: 3. Analytical strategies to reduce confoundingBMJ, 2005
- Neuromuscular manifestations of critical illnessMuscle & Nerve, 2005
- Effect of neuromuscular blocking agents on gas exchange in patients presenting with acute respiratory distress syndrome*Critical Care Medicine, 2004
- A comparison of confidence interval methods for the intraclass correlation coefficient in cluster randomized trialsStatistics in Medicine, 2002
- Assessing the outcome of pediatric intensive careThe Journal of Pediatrics, 1992
- The Robust Inference for the Cox Proportional Hazards ModelJournal of the American Statistical Association, 1989